抄録
It is reported that blood urea nitrogen (BUN) rises up logarithmically with advancement of renal dysfunction, and serum guanidinosuccinic acid (s-GSA) rises in parallel with BUN, but there is no mention about the rising pattern of s-GSA during the course of CRF. In order to investigate the significance a rising pattern of s-GSA in relation to the progression of renal damage, we measured serum creatinine (s-Cr), BUN, and s-GSA in 79 patients with CRF due to chronic nephritis or polycystic kidney disease recieving conservative therapy. The paramater of renal function, we use the reciprocal of s-Cr(1/Cr). The logBUN was significantly in negative proportion to 1/Cr (logBUN=-1.33×1/Cr+2.21 r=-0.845 p<0.01 n=69). The correlation between BUN and logGSA was also significant (logGSA =0.012×BUN+1.50 r=0.801 p<0.001 n=69), and the relationship between logGSA and 1/Cr was in negative proportion (logGSA=-2.81×1/CrH-2.97 r=-0.772 p<0.001 n=78). These results suggest that in which 1/Cr remains relatively high, the rising rate of s-GSA was lower than that of BUN, but as the renal damage advanced to the critical state of renal failure, in which 1/Cr approached a critically low level, rising rate of s-GSA became abruptly higher than that of the BUN. The s-GSA is a more sensitive marker of the changes of renal function in the critical period of CRF.
