Renal function and urinary prostaglandins in rats given an adenine diet

TAKAKO YOKOZAWA; HAE YOUNG CHUNG; TAE WOONG LEE; HIKOKICHI OURA

doi:10.14842/jpnjnephrol1959.31.671

TAKAKO YOKOZAWA, HAE YOUNG CHUNG, TAE WOONG LEE, HIKOKICHI OURA

著者情報

キーワード: renal failure, renal function, prostaglandin E₂, 6-keto-prostaglandin F_1α, thromboxane B₂

ジャーナルフリー

1989 年 31 巻 6 号 p. 671-675

DOI https://doi.org/10.14842/jpnjnephrol1959.31.671

詳細

抄録

The glomerular filtration rate (GFR), renal plasma flow (RPF) and renal blood flow (RBF) were all markedly decreased in rats given an adenine diet as the period of adenine administration lengthened. Concurrently, the urinary excretions of prostaglandin E₂ (PGE₂) and 6-keto-prostaglandin F_1α (6-keto-PGF_1α) decreased gradually in parallel with the renal function parameters, whereas the urinary excretion of thromboxane B₂ (TXB₂) increased markedly. These findings suggest the involvement of prostaglandin in the renal circulation.

責任著者(Corresponding author)

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