慢性腎不全患者の栄養障害に対する遺伝子組み替え成長ホルモンの治療効果

抄録

Recombinant human growth hormone (r-hGH), 1 U/kg body weight/week, was administered subcutaneously for 2-4 weeks to two end stage renal disease patients with severe malnutrition, Following r-hGH, there were significant increase in hematocrit level and serum conceetration of albumin, IGF-1 and GH, and decrease of urea nitrogen. It was concluded that r-hGH exerts a therapeutic effect to nutritional status in renal failure patients by improving severe hypoalbuminemia, susceptibility to infectious disease, intractable ascites and so on.