グリセロール誘発急性腎不全における腎および全身循環動態

―チオアセタマイド誘発肝硬変ラットにおいて―

抄録

In our previous papers, we reported change in the systemic hemodynamics in rats with glycerol-induced acute renal failure, as estimated by the microsphere method. It was found that the develop-ment of acute renal failure related not only to renal blood flow, but also to the hepatic blood flow. In view of the liver playing an important role in the metabolism of substances, such as drugs, and in blood circulation, we examined changes in the systemic circulation and blood chemistry in rats with thioacetamide-induced liver cirrhotic, and those rats injected with glycerol. The result indicated that liver cirrhotic rats showed hypertension, higher levels of atrial natriuretic peptide (ANP) and lower levels of renal blood flow relative to the control rats. However, after glycerol injection, the development of acute renal failure was suppressed in liver cirrhotic rats. These results suggest that liver cirrhotic rats were in a hyperdynamic state and that this condition would be beneficial in the prevention of glycerol induced development of acute renal failure.