小児腎疾患における尿蛋白構成成分に関する研究(第2編)

―体位性蛋白尿と腎炎寛解例との比較―

抄録

The urinary protein components of 14 children with orthostatic albuminuria (group OA) and also that of 9 children with remission of IgA nephropathy or Henoch-Schönlein purpura nephritis (group GN) after forced lordosis were analyzed. The results were as follows; (1) Urinary total protein excretions after forced lordosis were greater than 30mg/dl in 50% of 26 children with remission of glomerulonephritis, therefore a high percentage of children with remission of glomerulonephritis were complicated with orthostatic albuminuria. (2) Urinary total protein excretions after forced lordosis were 150±9lmg/dl in the group of OA and 149±88mg/dl in GN (p<0.05). (3) In the urinary protein components, the percentage of urinary albumin and α1-antichymotrypsin excretions were significantly higher in the OA group than the GN group (p<0.01, p<0.001 respectively), while the percentage of urinary transf errin, IgA and IgG excretions were significantly higher in the GN group than the OA group (p<0.01, p<0.001 and p<0.05 respectively). (4) The ratio of urinary IgG/IgA and serum IgG/IgA was significantly lower in the GN group than the OA group (p<0.05), suggesting that serum IgA tended to be excreted in urine in the GN group.