Abstract

The Biopsy material taken from 18 cases which were diagnosed to be nephrotic symdrome of un-known origin on the clinical viewpoint. These were examined histologically as well as electronmicro-scopically, On the basis of electronoptic findings of mitochondria of the glomerular epithelial cell three types were postulated : A ; demonstrating severe enlargement of michondria including so-called myelin body. The latter being merely vacuolic rather peculiar is seen in concetric structure the shell of which is electron dense. Histologically sedan and PAS stainings failed to reveal neutral fat and mucopoly-saccharide, There were five cases assumed to be in this group which revealed mild nephrotic syndrome; lower proteinuria, almost normal cholesterinemia occasional edema and normal TP except for arbitural PSP excretion. B ; characterised by moderate enlargement of mitochondria, advancing disarrangement of crista, occasional electron dense granules in the glomerular epithelial cells. The basement membrane showed mederate thickning on lightmicroscopy and occasional fusion of foot processes. There were five cases being in this kathegory with occasional severe proteinuria and higher cholesterinemia. C ; show-ing almost normal mitochondria of the epithelial cell but rather severe thickning and flattening of epithelial foot processes. Eight cases were observed to be in the group exhibiting typical syndrome of nephrotisis and effective steroid and ACTH therapies. On the morphological and functional findings is drawn conclusion that the mitochondria of the glomerular epithelial cell would contribute to contaoll albuminuria with deformation of it. It would there-fore be mentioned that the protein leaking through the basement membrane could be taken in the cytoplasma the mitochondria of which play a role to manufacture it to from proteinuria of the ultafiltrate.