Abstract
1) The correlation of structure and function of human kidney in acute, subacute and chronic renal failure was studied, morphologically by microdissectional and histological methods. 2) In acute renal failure due to mismatched transfusion, changes of tubular epithelium were noted mainly in the distal tubules, while in the case due to toxic agents were found in the proximal as well as the distal ones. According to these findings, it is suggested that as a result of striking back duff u-sion of tubular fluid through the damaged epithelium, marked oliguria may occure. 3) In the case of subacute nephritis, membranous and exsudative changes in glomerulus and local 'hypertrophy with dilatation of lumens in the terminal portion of the proximal tubules were observed. According to these observations, the tubular dominant, as physiollogically suggested at a point of view in glomerular tubular balance, was also morphollogically supposed. This may result marked edema which affects unfavorably. 4) In human chronic renal failure, small mumbers of hypertrophied nephrons were observed in the contracted tissue. Formerly, it was assumed in my 1 st Report, that the renal function after partial resection of the Kidney in dogs were so similar to that of human chronic renal diseases. On account of these bases, it is suggested that the renal function of the human chronic renal failure may be done mainly by these small numbers of hypertrophied nephrons and not by the large numbers of atrophic nephrons. 5) In chronic renal failure, the tubular segmentation, so I called, one of the state of atrophic changes, were observed and the mechanism of the tubular segmentation were discussed by microdissectional method.
