Expression of chemerin and chemerin-R genes during adipogenesis of sheep preadipocytes

Abstract

In this study, we investigated the Gene expressions and functions of chemerin and chemerin receptor, during adipogenesis of sheep preadipocytes.  Our data showed that chemerin, chemerin receptor, adipogenic markers (PPARγ and C/EBPα) and inflammatory factor (TNF-α) gene expressions were increased at day12 after treatment with adipogenic induction medium.  Furthermore, chemerin induced lipolysis in differentiated sheep adipocytes and increased sheep preadipocyte proliferation.  These results demonstrate that chemerin regulates lipid metabolism and cell proliferation in sheep adipocytes.  The results also suggest that chemerin may play a role homeostasis regulator in sheep adipose tissue.