A SUPPLEMENTAL STUDY ON ACID PHOSPHATASE

Abstract

Using King-Armstrong's method, in which the substrate is disodium monophenylphosphate buffered at pH 5, I have determined the acid phosphatase content of human serum, of prostatic fluid in cases of prostatic cancer and some other urological diseases, of certain human organs and of various tissues of animals.
Report 1. On the serum acid phosphatase level (Addenda) Acid phosphatase content of prostatic fluid.
1) In various urological diseases except normal and prostatic cancer with bony metastases, serum acid phosphatase level was 0.1-2.6KAU*/100cc. There were no differences by sex and age. * King-Armstrong unit
2) Prostatic cancer with osseous metastasis (3 cases) showed specific remarkably high serum acid phosphatase content (5.1-26.7KAU/100cc), and after antiandrogenic therapy the content returned to normal along with the convalescence, but it increased again with the recurrence of the cancer.
3) After prostatic massage, serum acid phosphatase augumented rapidly; its maximum was at one hour after, and it gradually decreased to premassage values in 24 hours. The effect of massage is more remarkable in chronic prostatitis and benign prostatic enlargement than in the normal prostate gland.
4) The acid phosphatase content of prostatic fluids was strikingly higher than that of the serum, and it was especially higher in the cases of normal and prostatic hypertrophy (10 cases, 281-1163KAU/cc) than in cases of chronic prostatitis.