A STUDY OF RENAL CLEARANCE TEST IN THE UROLOGICAL SURGERY (II. REPORT)
THE RENAL CLEARANCE TEST AFTER THE PARTIAL NEPHRECTOMY (THE 1st. REPORT: A STUDY OF THE PARTIAL NEPHRECTOMY)
1954 Volume 45 Issue 9 Pages 561-567
Details
1954 Volume 45 Issue 9 Pages 561-567
The renal plasma flow (RPF) (with sodium para-amono hippurate), the renal blood flow (RBF), the glomerular filtration rate (GFR) (with sodium thiosulfate) and the filtration fraction (FF) were measured clinically and experimentally in order to discover damages of the renal function after the partial nephrectomy.
1. Clinical cases.
Renal clearance tests were performed on 9 clinical cases, containing 3 of renal tuberculosis, 3 of renal calculi and 3 of essential renal bleeding.
a. In patients who have another healthy kidney, changes of clearance tests after the partial nephrectomy were slight.
b. In a patient who has the one kidney, RPF was 280cc/min and GFR was 75cc/min on the 54th. postoperative day. There still remained a slight damge of the renal function
2. Experimental studies.
On 10 dogs renal clearance tests were performed to discover damages of the renal function immediately after the operation.
a. In all dogs, there were moderate damages of the renal function for 3 days after the operation, but gradually restorations occurred
b. RPF and RBF began to recover on the 5th. -7th. day after the operation. And in the 3rd. week after the operation RPF was 79. 4o and RBF was 78.5% of the normal value.
c. GFR required more days to regain the normal rate than RPF and RBF. GFR was only 66.2% of its normal rate on the 21st. day.
3. Conclusion.
Though the partial nephrectomy is accompanied with postoperative damages of the renal function, patients with another healthy kidney are not subjected to significant metabolic disorders after the operation, because the healthy kidney functions in compensation. On the other hand, patients with only one kidney face a crisis after the operation. After all the partial nephrectomy is a useful operation in the indicated cases, as damages of the renal function are reversible.
