A STUDY OF RENAL FUNCTION BY RENAL VEIN CATHETERIZATION
II. REPORT; RENAL EXTRACTION RATIO OF SODIUM PARA-AMINO HIPPURATE AND SODIUM THIOSULFATE
1956 Volume 47 Issue 3 Pages 151-164
Details
1956 Volume 47 Issue 3 Pages 151-164
In 75 kidneys of 53 patients with urological renal diseases, renal function was evaluated by measuring renal extraction ratio of PAH (EPAH) and STS (ESTS) by means of renal vein catheterization.
The results were as follows:
1) The mean of EPAH and ESTS of 20 normal kidneys was 88. 86±2. 99% and 25.21±4.08% respectively, which revealed nearly constant normal EPAH (82.3 to 94.6%, whereas widely ranged normal ESTS (19.4 to 33.8%)
2) The average of EPAH and ESTS of eight normal right kidneys was 90.7±2.4% and 24.6±3.94% respectively, that of 12 normal left kidneys being 87.6±3.7% and 25.6±4.2%, and thus revealing no statistically significant differences between right and left side. Sufficiently deep left renal vein catheterization was proved to enable to measure a reliable extraction ratio.
3) The average of EPAH and ESTS in pathological cases was as follows: In the first degree of damage of renal function, EPAH 76.9±9.59%, ESTS 18.6±5.3%: In the second degree of damage of renal function, EPAH 62.9±22.8%, ESTS 18.4±6.6%: In the third degree of damage of renal function, EPAH 13.9±12.4%, ESTS 10.8±6.9%. Contrast medium is not visible on intravenous pyelogram in cases where EPAH and ESTS are lower than 30% and 10% respectively. Accordingly this measurement of extraction ratio is most suitable in cases where intravenous pyelogram fails to show any excretion of contrast medium.
4) The measurement of the extraction ratio enables not only to show the degree of impairment of renal function, but also to establish a plan of treatment.
5) This method is also able to disclose the function of anuric kidney.
6) This is one of the most useful clinical tests which can demonstrate the separate renal function exactly.
