THE CLINICAL AND EXPERIMENTAL STUDIES ON THE PAROTIN (HORMON OF SALIVATORY GLAND) TO THE URINARY CALCULI

(1st Report) THE INFLUENCE OF THE PAROTIN TO THE EXPERIMENTAL URINARY CALCULI

Abstract

We carried out investigations on the influences exerted on the experimental bladder calculus, formed on a zinc plate nucleus, by the injections of parotin, a hormone secreted by the salivary glands, as well as by the presence or absence of the salivary glands. The Parotin used in the present investigations has been synthesized by Teikoku Zoki.
Albino-rats Weighing 100-150gm. were divided into 4 groups: the group 1 was used as the control; group 2 was given shots of parotin; group 3 was sialoadenectomized; and group 4 was given shots of parotin after having been sialoadnectomized. One mg. of parotin per 100gm. of body weight was injected every othr day. In order to measure the calculus deposit, groups 1 and 2 were followed up for 4 weeks, and groups 3 and 4 for 2 months. Of the 4 groups examined, a tendency to calculus formation was seen in group 3, while this tendency was less marked in groups given shots of parotin.
Parotin did not, however, have any influence on a bladder calculus which had already been formed around a foreign body, nor did it have any influence on a urinary calculus formed in mine fed on tibion or melanin.
The results of the present investigations indicate that parotin has an inhibitory effect only on the formation of the secondary bladder calculus alone. It seems that this is accounted for its action of accumulating calcium and phosphor.