We carried out investigations on the influences exerted on the experimental bladder calculus, formed on a zinc plate nucleus, by the injections of parotin, a hormone secreted by the salivary glands, as well as by the presence or absence of the salivary glands. The Parotin used in the present investigations has been synthesized by Teikoku Zoki.
Albino-rats Weighing 100-150gm. were divided into 4 groups: the group 1 was used as the control; group 2 was given shots of parotin; group 3 was sialoadenectomized; and group 4 was given shots of parotin after having been sialoadnectomized. One mg. of parotin per 100gm. of body weight was injected every othr day. In order to measure the calculus deposit, groups 1 and 2 were followed up for 4 weeks, and groups 3 and 4 for 2 months. Of the 4 groups examined, a tendency to calculus formation was seen in group 3, while this tendency was less marked in groups given shots of parotin.
Parotin did not, however, have any influence on a bladder calculus which had already been formed around a foreign body, nor did it have any influence on a urinary calculus formed in mine fed on tibion or melanin.
The results of the present investigations indicate that parotin has an inhibitory effect only on the formation of the secondary bladder calculus alone. It seems that this is accounted for its action of accumulating calcium and phosphor.

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A histological investigation was made in whole-tissue sections of 37 cases of bladder carcinoma (22 cases of segmental resection and 15 cases of total cystectomy).
1) As seen in whole-tissue sections, bladder carcinoma is considerably varied in histological appearance in different parts of a tumor mass. Histologically, the growth of bladder carcinoma should be considered on the basis of the structure of the cancer mass seen as a whole.
2) The non-sprouting-type may be considered as histological sign of non-accelerated carcinoma growth, while the sprouting type shold be understood as histological manifestation of accelerated carcinoma growth; the so-called lymphatic-and blood-vessel-permeating form (L-form) may be another histological picture of carcinoma in its stage of accelerated growth.
3)This classification may by available in determining the postoperative prognosis of the condition, when the entire tumor mass of bladder cancer is of the non-sprouting type, a postoperative longevity can be expected for the patient. The slightly sprouting-type may be taken to warrant favourable prognosis. A picture of metastatic lymph nodes may be taken as a condition affecting the postoperative course.
4) The above-described picture of the sprouting and permeation may be taken as an histological picture representing the “schub” of carcinoma.
5)This classification of the types of cancer growth is available in determining the histological estimation of the postoperative prognosis of bladder carcinoma and is expected to make good the defects of the methodes of Broders and Jewett, etc.

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In autotransplanted kidney into the neck which was performed in 33 dogs, the condition of kidney immediately after the transplantation was evaluated especially from the standpoints of arteriography and histological findings.
The results may be summarized as follows:-
1) The arteriography of the transplanted kidney revealed no spastic contraction as was often the case in the remaining kidney after its partial nephrectomy.
Radiologically the circulatory condition of a transplanted kidney was nearly normal. However, the exact parallelism between arteriography and renal function was not recognized.
2) Usually only the slight histological change was observed in the kidney immediately after transplantation, which was understood as being due to operative intervention, while considerable degree of it was limited to the cases to which the function of a transplanted kidney was far out of normal.
3) The circulatory disturbance of a transplanted kidney has not yet been fully understood, upon which the function of a transplanted kidney may largely depend.
4) The series of my experiments proved that the homotransplanted kidney was one of the valuable procedures in case of acute renal insufficiency for temporary compensation.

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I. Clinical Study
1) Renal clearance studies (CSTS, CPAH and TmPAH) were performed on 19 cases of chronic lower urinary tract obstruction. The cases whose clearance had fallen more than 50 per cent of normal value were found in one-third of all cases by means of CSTS determination, in half by CPAH and in one-fourth by TmPAH respectively.
The clearance speed of PAH (Dost's Halbwertzeit) very often was delayed as much as over 35 minutes in patients with chronic lower urinary tract obstruction, compared to normal average of 22 minutes.
2) Renal clearance test about one month after prostatectomy, showed a fair improvement not only by TmPAH determination but also by CSTS in some cases.

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In 18 Cases of unspecific epididymitis in which Gonorrhoe were not clinically detectable and which were not tuberculous nor syphilitic, we made study of the dispositions and resistibility against antibiotic of the bacilli which were chiefly cultivated from the tissue fragments taken out of the most affected swelling parts with VIM-Silverman Biopsy Needles by steritized methods, and also made histological and clinical researches as well as observation of mechanism.
The results of the study are as fallows;
1) We had 23 strains from the 18 Cases. Of the 18 cases, 11 were single infection, 5 mixed, 2 non-bacillar. In the last 2 cases, the patients received antibiotic treatments before the examination.
2) The bacilli of the strains were classified as 15 Staphylococci, 4 Corynebacterium, 1 Aerobacter, 1 Proteus, 1 Micrococci and 1 Candita.
3) Staphylococci was weak in infection force and sensible to such antibiotics as Oxytetracycline, Chlortetracycline and Chloramphenicol. However, 2 of the strains showed resistibility against Panicillin, 3 against Dihydro-streptomycin and the most against Sulfaisoxazol.
4) Although the tissue fragments were small from the histological point of view, we intended mostly to prove the cases unspecific. The microscopic examination showed unspecific and suppurative inflammation in general at the same time Endo-arthritis and 1 or Fibrose in some cases.
5) In the clinical diagnoses of the 18 Cases, 12 cases were acute, 11 were on left side epididymis and 1 was an both side epididymis. As for the combined disease, nongonorrhea urethritis was noticed only in 2 cases.
6) In 10 of the 18 cases the cause of the disease was unknown and 6 came after contusion. Considering the bacalli showed no particular disposition and were weak in infection force, we would like to believe that contusion was a cause which made epididymitis occure easily, inducing disordes in the circulation system of the blood, and lessening resistibility of the Organ.
7) Jndging from the that the most cases are those of staphylococci, it may be safely said that the bacilli are carried through liquid circulation. and so, we would like to give the most attention to the lymphatic gland along the vas deferens.

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