HORMONE AND RENAL FUNCTION

II. ANTERIOR PITUITARY- AND ADRENAL CORTICAL HORMONES AND RENAL FUNCTION

Abstract

The effects of anterior pituitary hormones (Hypophorin and ACTH) and adrenal cortical hormones (Interenin and DOCA) on renal functions were investigated on mature male rabbits by measuring GFR and RPF respectively with Creatinine clearance and with PAH clearance. The kindey function was tested in every experiment on 8th and 15th days during daily administration of the hormones in a therapeutiis dose, and, further, in 2 weeks after the cessation of giving the hormones.
The results obtained were as follows:
(1) Anterior pituitary hormones: Both GFR and RPF, especially the latter, increased gradually in a slight degree from 8th to 15th day after the administration of ACTH (Armor), while nothing effective was revealed by the administration of Hypophorin (an extract of the pituitary anterior lobe of a cattle).
(2) Adrenal cortical hormones: Both GFR and RPF showed an increaes by the application of DOCA, whose degree was more remarkable in GFR, and rather, less considerable in RFP than when ACTH was given, while no effect was found by the administration of Interenin (an extract of adrenal cortex of a cattle). The increase of GFR and RPF, resulted from DOCA administration, returned to normal completely in 2 weeks after the discontinuance of administration of DOCA.