STUDIES ON THE LOWER URINARY TRACT OBSTRUCTION (VI. REPORT)

RENAL CLEARANCE TEST IN LOWER URINARY TRACT OBSTRUCTION

Abstract

II. Experimental Study
1) The effect of 24-48 hours acute urinary retention on renal clearance was studied in dogs. The GFR showed no marked change, the ERPF was variable, but the TmPAH was evidently decreased, when they were determined several hours after the relief of the obstruction.
2) The effect of raising the intravesical pressure upon the kidney functions was studied, when the connection between the bladder and the kidney was cut by ureterocutaneostomy. During the maintenance of high intravesical pressure, the GFR was generally reduced and the ERPF was variably changed. But the rate of reabsorption of water was increased only in one of three cases.
3) The influence of raising intrapelvic pressure on the renal functions was studied by observations of urine flow, CSTS, TmPAH CNa and Ccl. These functions were apparently reduced while the intrapelvic pressure of 19mmHg was maintained in three of the four cases. When the pressure was gradually raised to 30mmHg and maintained there, the functions were apparently much more reduced in all cases. Then, by lowering the pressure, they rapidly tended to recover. The rate of reabsorption of water and Na were definitely increased in all cases during the continuance of high intrapelvic pressure.