STUDIES ON RADIO-ISOTOPES IN THE UROLOGY (I. REPORT)

APPLICATION OF CESIUM¹³⁷ NEEDLES AND YTTRIUM⁹⁰ COLLOID TO THE MALIGNANT TUMORS OF THE UROGENITAL ORGANS

Abstract

The author applied the Cs¹³⁷ needle or Y⁹⁰ colloid, which were made available by courtesy of the Department of Radiology of our school, to the treatment of genito-urinary tumors and obtained results as follows:
No serious complications were noticed. But irradiation cystitis was innevitable, especially in case of Cs¹³⁷ stinging. ACTH was found to alleviate the cystitic symptoms and prevented the occurring of fibrosis.
The author observed the histological influences of Cs¹³⁷ and Y⁹⁰ on the urinary bladder or prostate of mongrel dogs and counted the distribution of Y⁹⁰ in the regional lymphatic glands and various organs.
Summarizing the clinical and experimental cases, the principal histological changes with these radio-isotopes are successively, an immediate acute inflammation, hyaline degeneration after a week, fibrotic proliferation in one to three months and later fibrous replacement. Generally speaking, these changes coincide with the report of Berg and Bulkley who used Au¹⁹⁸.
It may be concluded, therefore, that the present status of treatment with radio-isotope necessitates its use in combination with operation therapy because of the incomplete distribution of isotopes to the regional cancerated lymphatic nodes.