1958 Volume 49 Issue 6 Pages 554-560
In the previous paper, a report was made on the findings of the metachromatic reaction of urine collected from the rabbits experimentally infected with tubercle bacilli. In the present paper, pathohistological findings of the rabbits used in the above experiments will be discussed in relation to the findings of metachromatic reaction of their urine.
Leasions produced in the rabbits inoculated with tubercle bacilli into the auricular vein were heavy milliary tuberculosis of both lungs and mild one of the liver and the kidney. No lesions were detected in the ureter and the urinary bladder.
While, the lesions formed in the rabbits inoculated with tubercle bacilli into the left renal artery were mostly heavy milliary tuberculosis of both lungs and the left kidney with mild lesions in the liver. In some cases, however, tuberculosis nodules were formed in the left ureter and the urinary bladder.
No lesions other than tuberculous changes were observed in the experimental rabbits and no lesions were detected in the control rabbits.
In view of the findings stated above, together with the results of previous study, the author believes that the presence of tuberculous lesions in the viscera is one of the most important factors to cause positive metachromatic reactions of urine.
