HISTOPATHOLOGICAL STUDIES OF TUERCULOUS KIDNEY, TREATED WITH RENAL PELVICAL IRRIGATION OF SM-INAH SOLUTION

Abstract

With respect to the pathological histological observation on a tuberculous kidney which was administered of renal pelvical irrigation with antibiotic solution (Streptomycin and INAH), and fluorescens microscopic observation on tubercle bacillus, following conclusions were obtained from comparing and Study of comparative examples in this research.
1. The effect of the administration of the irrigation therapeutics on the pathological histological observation, is conspieuous on the foci of pelvic renalis. That is to say mainly purification and disappearance of tubercls bacillus accompained by the decollement of the caseation is conspicuous on the tuberculous foci which spread out in the pelvis renalis.
Its degree was not always proportional to the amount of streptomycin of intra muscular injection which was used at same time, but was proportional to the number of the days the irrigation was administered. The more the number of the days of the irrigation was administered, was better the result. However, proportional to the amount of streptomycin of intra muscular injection administered at same time, the effect of therapeutics on the parenchyma is great. also, better the recovery of the focus of the pelvis renalis the recovery of the focus of renal parenchyma is good.
2. As the observation which approximately corresponds with the description of predecessors, tuberculousknots in the renal parenchyma are contabescence of epithelioid cyst and appear to be dispersed.
There are many of those which indicate the penetration of lymphocyte and cellulor infiltration in circumference is scarce. Only slight degree in small area or it could not be found at all.
Langhans's giant cell also indicates the inclination of atrophy, deformation and disappearance.
Circling of the gitter faser against the knot is good and there are many which penetrate in the knot. The inclination of fibrosis or reduction was conspicuous. also in the knot which accompanies the caseation at the center, the circling of the gitter faser is well but the penetration into focus of center caseation is less. At the place where the fibrosis or hyalinosis of Glomerus, hypertrophy of Bowman's capsule, disappearance of nephritic duct, and the diffusible proliferation of the connective tissue, are strongly observed, the infiltration of small round cell is strong and inclination of recovery is slight.
There are many cavitary wall which schowed fibrillary hypertrophy, and large collagen fiber wrapped them, and fine gitter faser runs between them and appeared to be a fine net.
3. The regeneration of epithelium was recognized at the recovered place of the urcerative wall or cavitary wall. Commencement of the regeneration is started from the fine gitter faser covered the epidermis cuticle which was expanded hydropically on exposed tuberculous granulation tissue and on top of that, by basing it, the epidermis cuticle was regenerated in the imperfect shape of monoptychic or stratification from healthy edge portion.
The uniformed formation of transitional epidermis cuticle was not observed.
Submucous coat of renal pelvis generally shows hydropic appearance. However, between the example of irrigation and that of Streptomycin with intra muscular injection, the great difference was not always recongnized by the observation of lesion in renal parenchyma only.
4. Concerning tubercle bacillus Tubercle bacillus, in control the focus of the renal pelvis which is the main position of many tubercle bacillus, is purified by the administration of irrigation therapeutics and in accompanying it, tubercle bacillus is decreased suddenly and has great difference from control. Because of this, the progress of the lesion is rapidly ceased and as a whole the inclination of the recovery became conspicuousely great.
5. Judging from above observations, the administration of the irrigation therapeutics in the renal pelvis produced the most excellent result compared with contr