前立腺肥大症及び前立腺癌に於ける膠原量について

抄録

The collagen content in the prostatic tissues surgically removed from 54 patients with prostatic hypertrophy and prostatic carcinoma was measured by the Ishida's method, the modification of the Neuman and Logan's method. The collagen content was also measured in 7 normal cases for control.
The results obtained were compared with the histological picture and summerized as follows:
1) The average value of the collagen content in normal prostatic tissue was 6.3 per cent.
2) The average value of the collagen content in prostatic hypertrophy was 9.8 per cent, higher than normal value.
The average value of the collagen content in the fibroglandular type and the mixed type which contains abundant stroma was 10.4 per cent and 10.9 per cent respectively, both somewhat higher than in the glandular type, 8.6 per cent.
3) The average value of the collagen content in prostatic tissue which showed histologically microfollicular hyperplasia was 9.8 per cent, same value as in general cases of hypertrophy.
4) The average value of the collagen content in occult carcinoma was 11.9 per cent, practically as high as in prostatic carcinoma.
5) The average value of the collagen content in prostatic carcinoma was as high as 12.0 per cent, about twice as normal value. The average value of collagen content in adenocarcinoma was 11.3 per cent, while that of scirrhus was 13.3 per cent.
6) From the view point of collagen content, the prostatic carcinoma is different from the prostatic hypertrophy and the occult carcinoma may be considered to be identical with the clinical prostatic carcinoma, while the microfollicular hyperplasia may be one type of the prostatic hypertrophy.