A STUDY ON RADIOISOTOPE RENOGRAM

Abstract

Concerning radioisotope renogram, following investigations were made in respect of: 1) the requirements for measuring apparatus and its measuring method, 2) the results of animal experiments and 3) on the appraisal of its clinical application.
1) The measuring apparatus were fixed with a collimeter and a discriminater, thereby accuracy was highly assured. As to the measuring method, the dosage was fixed at the rate of 4μc per 10kg body weight, and examinees were given diuresis to accelerate the urination. Measurements were taken mainly in sitting position. The test materials were: ¹³¹I-Diodrast, ¹³¹I-Urokon and ¹³¹I-Hippuran.
2) The experiments were conducted with ¹³¹I-Diodrast on adult dog, with normal kidney, with stricture of renal arterie, with hydronephrosis, with absence kidney, etc. The normal renogram curves shows three segments which are characteristic of normal kidney, especially the renal tubular function and retention in the renal pelvis were clearly indicated. The renogram of diseased kidneys show varied curves of the split function, correspondingly to each cases.
3) Clinical experiments consist of 381 cases; namely 350 Diodrast cases, 21 Urokon cases and 10 Hippuran cases. For the analysis of renogram, renal vascularity value, retention rate, maximum count, peak time and half crest count time etc. were determined as the normal renogram base factors. A close relationship were observed between the qualitative classification of renogram curves and fraction data of p. s. p test.
The clinical application also proved that renogram was useful in the practice of determining various values in clinical cases, suggestes its useful application not only in urology but also in field of internal medicine.