前立腺癌に対する抗男性ホルモン療法の作用機序についての研究

第2報 性ホルモン投与による前立腺の組織学的, 組織化学的並に全身的影響についての実験的研究

抄録

The variations of serum sodium, potassium and chloride levels, serum total acid phosphatase and serum prostatic acid phosphatase activities, and histological and histochemical changes of prostate were examined in the white male rabbits (body weight: about 2kg) which were treated by synthetic estrogen, androgen and cortisone for about 3 weeks. In the prostate of rabbits administrated synthetic estrogen, irregular arrangement and atrophy of the epithelial cells, pyknosis of nuclei, bag like enlargement of glandular cavities and atrophy of stroma were observed. These histological changes of prostate, especially in the rabbits which were treated high doses of estrogen with castration were more demonstrable. In the cortisone administing group the degenerative changes of epithelial cells in the prostate generally were slight. Alkaline phosphatase reaction in prostatic tissue of the rabbits administrated with high doses of estrogen decreased relatively in the epithelial cells, and relatively increased in the basement membrane. In the androgen group, the phosphatase reaction decreased in epithelial cells, and increased in the basement membrane. The serum sodium, potassium and chloride levels generally were not changed in the course of these hormone administration.