CLINICAL STUDY ON NOCTURNAL ENURESIS

I. THE THERAPEUTIC EFECTS AND REMOTE RESULTS OF VARIOUS KINDS OF TREATMENTS

Abstract

The outpatients with nocturnal enuresis in Urological Department of Hirosaki University for the past 1.3 years (1946 to 1958) were examined statistically, and investigated especially with respect to the effects of various therapeutic procedures.
The results obtained were as follows.
1) 285 patients in total were found, which corresponded to 5.5% of 5107 urological patients. The highest frequency was 12.7% in 1947 and the lowest 2.7% in 1955.
As to age, 70.1% of 285 patients were under 15 years old and corresponded to 32.6% of 613 urological patients under 15 years old.
2) Of 250 cases treated with various kinds of treatments, 175 cases (70%) were clinically improved. Comparing the direct effects of these treatments, 65 cases (85.6%) were improved in 75 cases by the combined treatment of Cathelin's epidural injection and internal use of Pervitin, which showed the highest rate of improvement, and next, 38 (77.5%) in 49 cases by Cathelin's injection only.
The above mentioned rates of improvement might be apparently higher than that of 50% in 20 cases by local injection of Imidalin into the bladder wall.
3) In 83 cases, the further course after treatment was pursuited for 6 months as the shortest and 11 years as the longest, and these remote results were compared by the kind of treatments. The combined treatment of Cathelin's injection and internal use of Pervitin showed the highest cure rate of 76.0% (19 out of 25 cases).
Excest the internal use of pervitin only, the cure rates in remote results were lower than the direct cure rates.
4) According to this examination on remote results, the relapse of enuresis was found in 17 cases (23.4%) out of the 47 cases who had been decided as cure at the time when the treatments were discontinued. On the other hand, it was assumed that socalled natural cure owing to growth was found at 32.4%≥P≥8.2% in the far improved cases (confidence limits 98%).