EXPERIMENTAL STUDIES ON THE MECHANISM OF URINARY TRACT INFECTION

ON THE HEMATOGENOUS INFECTION

Abstract

In the rabbit, sensitized previously with homologous exudate of rabbit bladder, a typical cystitis was produced by urogenous administration of Escherichia coli, but not by staphylococcus,
In this paper bacterio-pathological change of urinary tract in the rabbits is discussed, intravenously injected by 0.5mg to 1mg of Escherichia coli and staphylococcus respectively after the sensitization with previously discribed method.
Following the intravenous injection of Escherichia coli same tendency of bacteria discharge and pyuria which is not same degree occur in all rabbits. Inspite of the mild change of kidney, the pathological change of urinary bladder is of distinct inflammation.
Following the intravenous administration of staphylococcus, different degrees of bacteria discharge which may be due to variation of the species are seen. The cases of severe pyuria are associated with infiammatory change of both kidney and bladder.
On the other hand the cases of mild bacteria discharge show slight change of kidney with intact bladder. Therefore this means that staphylococcus may produce more easely inflammatory change in kidney than in bladder.
As the conclusion, both urogenous and hematogenous cystitis of Escherichia coli are observed in the rabbit in which the antigen-antibody reaction is supposed, while, on staphylococcus, hematogenous cystitis is only noted by the same reaction in the some rabbit.