腎結石発生機序に関する実験的研究

第2篇 腎に於ける抗原抗体反応に伴う石灰沈着惹起時の尿及び血清ムコ蛋白, 尿保護膠質の変動を中心とせる2, 3の生化学的研究, 並びに病腎の病理学的, 組織化学的研究

抄録

Renal shock was induced by injecting guinea pig serum sensitized by rabbit red cells into the renal artery of the rabbits, and histochemical changes in the kidney caused by this reversed anaphylaxis were found.
Mucoprotein in both urine and serum, protective colloids in urine and calcium values were measured.
In addition, histochemical studies of kidney were also carried out (by the method of PAS and Von Kossa stain).
1) The excretion of urinary mucoprotein evidenty increased in two or three days after the development of nephritis.
It was recovered to the control levels in 5th to 7th day with some variation. Serum mucoprotein also increased and showed correlation between urinary mucoprotein.
2) Protective colloids in urine also increased.
3) Any significant change in urinary and serum calcium levels were not seen.
4) Histochemical section of the kidney showed the picture similer to acute localized nephritis, but there were few changes in renal tubules.
Gromerulus, tubular epithelium and tubular casts were positive by PAS stain. This appearance may be due to the following conditions: (1) the increased permiability of blood vessels, (2) the degeneration of tubules, (3) the changes of reabsorption capacity of tubules caused by allergic nephritis.
Relation between renal calcification and allergic nephritis was discussed, and emphasis was made that alteration of urinary and serum mucoprotein in allergic nephritis may be considered as a cause of calcification in kidney.