生体内通電時に起る線維素溶解酵素系の変動についてセロトニン及び抗セロトニン剤
(ペリアクチン) の実験的腎出血及び線維素溶解酵素系に及ぼす影響
1965 年 56 巻 3 号 p. 297-304
詳細
1965 年 56 巻 3 号 p. 297-304
Serotonin is considered a kind of shock-producing substances and its physiological and Pharmacological properties have gradually been elucidated by many investigators since its discovery by Rapport in 1948.
Using rabbits, investigations were carried out on the participation of Serotonin in producing renal hematuria which may be explained by Reilly's phenomenon, as well as, on the effect of Serotonin on the fibrinolytic enzyme system in vivo, and the effect of an anti-serotonin agent, Cyproheptadine (Periactin: Nippon Merck-Banyu), on the renal hematuria and the fibrinolytic enzyme system.
1) Serotonin, immediately after an intravenous injection, increased plasminogen or proactivator in the blood transiently. While, it showed almost no influence on the fibrinolytic enzyme system in urine, and it did not induce hematuria. There was no increase in the urinary excretion of 5-HIAA (by the method of Sjoerdsma et al.).
2) In the case of Reilly's phenomenon, there was no urinary excretion of 5-HIAA.
3) In the renal hematuria caused by Reilly's phenomenon, Serotonin showed a slight inhibitory tendency by the retrograde infusion in the renal pelvis. Its effect on the fibrinolytic enzyme system in the blood was complicated.
4) Periactin inhibited the renal hematuria caused by Reilly's phenomenon, and also inhibited the fibrinolyic effect of urine. By administration of Periactin, moreover, the increase of plasminogen or proactivator in the blood was inhibited and the mucous membrane of the renal pelvis acquired fibrinolytic ability.
