1966 Volume 57 Issue 5 Pages 482-490
Severe renal insufficiency has been known to develop in diabetics and it is also a well known fact that bacillary infections, especially pyelonephritis, are often complicated. This pyelonephritis may be thought to play a roll to accelerate the diabetic renal insufficiency. Diabetic renal changes have been studied clinically, few detailed observations, however, have been done on those of experimental diabetic animals. Therefore renal changes of dogs were studied in which alloxan diabetes was induced.
Pyelonephritic changes were seen in high percentage as much as 12 of 16 dogs (75.0%), i. e. infiltration of inflammatory cells into the papillae, and the interstitial tissue with increased connective tissue. No causative organism of the inflammatory changes was identified. All the 16 dogs had shown some diabetic renal changes; endothelial and mesangial thickening, lobulation and hyaline degeneration in the glomeruli, fibrous thickening in Bowman's capsule and formation of hyaline cast, various sizes of the lumens and epithelial degeneration in the renal tubules and thicking and hyaline degeneration in the mediumsized and small arteries. Regarding a relationship between urinary and blood suger levels and histological changes of the kidney, the renal changes were domparatively slight in dogs in which the elevation of these suger levels was moderate. On the other hand renal changes increased progressively with the elevation of the levels. As for the duration of diabetes, no clear-cut relationship was demonstrated to the histological changes of the kidney.
