1966 Volume 57 Issue 6 Pages 619-631
1) Clinical study on undescended testicle of 87 cases were done. On HCG treatment of 46 cases, complete descent into the scrotum were noted on 19 testes out of 67 testes (28.4%); in addition another 15 testicles showed some descent but not into the scrotum. In testicular descent bilateral cases responded to HCG much better than unilateral cases.
2) Some delay of the bone age on the cases of undescended testes and male pseudohermaphroditism were noted.
3) Statistical analysis was done on somatic growth of the cases of unilateral undescended testes, bilateral undescended testes and male psuedohermaphroditism. There was no significant difference among these three groups.
4) HCG accelerated the growth of body length but not the body weight statistically. In our clinical experience it also promoted the growth of bone age. These action was not related to the success of the testicular descent.
5) There was no influence on the excretion of urinary 17-ketosteroids during the HCG treatment. HCG administration test in these patients showed no difinite pattern in urinary 17-ketosteroid excretion.
6) Side effect (virilism) of HCG was noted in almost all cases. This seems to be the definite evidence of hormonal effect of HCG through testis. It strongly suggests the increase of androgen which could not be detected with the crude measurement of 17-Ketosteroids in these young patients.
7) The mechanism of descent of testis was thought to be the action of stimulated testis of HCG. The abnormal Gubernaculum Hunterii might be one of the causes for the failure of HCG treatment on the undescended testicle.
