A STUDY ON RENAL TRANSPLANTATION: AN EXPERIMENTAL STUDY ON RENAL HEMODYNAMICS IMMEDIATELY AFTER RECIRCULATION OF THE BLOOD

Abstract

Activity of the arterial system of a transplanted kidney was observed in dog experiment. The arterial activity or hemodynamics was apparently affected within a few minites after transplantation by a sort of various washing-out solution.
It reflects a possible influence for the graft function immediately after recirculation of the blood in renal allotransplantation.
After ten varieties of washing-out solutions which differ in costitution and temperature were used, renal arterial blood flow and renal arterial pressure were estimated immediately after vascular recirculation of the autografted kidney of the dog.
1) The autografted kidney washed-out with physiological saline resulted in significant decrease of the renal blood flow, causing by interstitial edema. Washing-out of the kidney with low-molecular weight dextran at low temperature (4°C) also resulted in decrease of the renal blood flow, however, a good blood flow was obtained when low-molecular weight dextran was used at 37°C.
Decrease of the blood flow at 4°C was not observed, when procain was added into the washing-out solution.
2) A transient decrease of the blood flow was found during a period of 3 to 5 minutes after recirculation in every group, even when it showed a good renal blood flow immediately after autotransplantation. This phenomen is considered to be an effect of a transient retention of one of peripheral vaso-constrictive substances.
3) It was proved to be a vaso-constrictive substance by autotransplantation-modified experiment with adding papaverin into the washing-out solution.
4) From the results of our experiment, it is concluded that, the most adequate solution for washing-out requires to the use of low molecular weight dextran with adding heparin, procain as well as papaverin.