CLINICAL AND EXPERIMENTAL STUDIES ON INFILTRATION OF EARLY URINARY BLADDER CARCINOMA

Abstract

Results of treatment were studied in cases of early stage cancer of the urinary bladder, and some expermental studies were performed in which Brown-Pearce tumors were inoculated into vesical walls of rabbits to produce experimental tumors for clinical evaluation of early bladder cancer on the basis of types of growth and tumor cell.
1) During the 20-year period, 152 cases of early stage cancer of the urinary bladder were treated with fulguration and partial cystectomy in our hospital and fulguration group was better than the other on a 5-year survival rate.
2) Types of growth and tumor cell seem to be important for overall clinical evaluation on early stage cancer of urinary bladder.
3) Growth of early stage cancer of the urinary bladder are classified into 4 types; P (papillary type), S (surround type), W (wide type) and I (infiltrate type).
P and S types represented true low grade and low stage, while W and I type indicated poor prognosis in spite of early stage.
4) Brown-Pearce tumor was transplanted experimentally into the vesical wall (vertex and trigonum) for the production of the protruding tumor in the vesical cavity.
5) Implanted tumors resembling early clinical cancer of the bladder were obtained one or two weeks after the submucosal inoculation in the vesical wall.
These tumors had a low stage frequently due to the resistance of muscle layer in spite of high grade in the cell type.
In the group inoculated into deep muscle layer, a rapid progress to the infiltrative type was indicated
6) Cystoscopic growth form of tumor and grading of the tumor cell by biopsy are important for the selection of therapeutic method in early bladder cancer.