睾丸機能の研究
第1報 血中 Testosterone 測定による睾丸内分泌機能の検討
1971 年 62 巻 12 号 p. 925-943
詳細
1971 年 62 巻 12 号 p. 925-943
1) A slight modification of competitive protein binding assay for plasma testosterone of Maeda was studied. 0.25ml of male plasma was sufficient for the assay.
2) The change of plasma testosterone level by aging was studied in men. The prepubertal level was 80.92±44.12ng/100ml. That sharply increased between 15 to 19 years of age and reached to the maximum level (670±239.11ng/100ml) in twenties. And then it was gradually decreasing with age. The level in sixties was 334.16±77.54ng/100ml.
3) The decreasing process of plasma testosterone level after castration was examined in detail. A 50% deduction was found after 2 to 6 hours and plasma testosterone level reached the prepubertal boy's level after 12 to 24 hours.
4) The effect of five days' H. C. G. (5, 000IU) administration on plasma testosterone concentration in normal adult male was studied. The increase in the plasma testosterone level was persistent for a few days even after the cessation of administration.
5) After intramuscular injection of 100mg of testosterone propionate the rise in the plasma testosterone level in two normal males rapidly reached a peak in 1 to 5 hours and declined to the base line level in 48 hours. However, in castrated patients, the level slowly reached a peak after 8 to 12 hours and returned to the normal value after 36 to 48 hours.
