ENZYMOLOGICAL STUDY OF PROSTATIC CANCER

VI. Serum Acid Phosphatase Level and Prognosis of Patients with Prostatic Carcinoma

Abstract

For 58 cases with carcinoma of the prostate, the interrelationship between clinical effect by antiandrogenic treatment with castration and stilbestrols and change of serum acid phosphatase levels were studied and the following results were obtained.
1. Pretreatment serum total and prostatic acid phosphatase levels had no significant correlation with five-year survival rate.
2. Patients responding with a decrease in the serum acid phosphatase level to the antiandrogenic treatment showed better therapeutic response one year after the start of the treatment and a higher fiveyear survival rate than those who responded with an increase.
3. For diagnosis and as an index of treatment in patients with prostatic carcinoma, prostatic serum acid phosphatase was not specific more than total serum acid phosphatase.