HYDROSTATIC PRESSURE TREATMENT FOR MALIGNANT LESIONS OF THE URINARY BLADDER

Abstract

With a certain criteria of the clinical effects due to hydrostatic pressure technique for carcinoma of the urinary bladder, the results of 25 cases obtained with this method consisted of 10 cases with a dramatic response, 8 cases with satisfactory effects and 7 cases with fairly good response, except for only 1 case ensued by carcinoma death. The speciality of hydrostatic pressure technique is essentially belonged to immune therapy, with experimental elucidation of immunological mechanism by Hashimoto. With easy judgment of its effects in rather short period after the procedure, hydrostatic pressure technique should be applied not as a tentative treatment but as the first choice procedure especially on cases beyond transurethral surgery. Estimation of increased cases without any necessity of total cystectomy might be emphasized, with exact application of this method based on both host qualification and tumor conditions.
The method indication is summarized as follows; tumor factors are composed of their locations, growth patterns and stages of their advancement. Tumors occupying within 10mm. around ureteral orifices showed marked resistance to the treatment. Sessile carcinoma usually showed a relatively poor response which might be resulted in the fragility of the bladder wall caused by cancer infiltration. The host reactions were parallel to positive degrees of tuberculin skin test or a number of lymphocytes in peripheral blood and/or in tumor tissues.