再生力を利用した膀胱補填部の血流支配及び神経再生に関する研究

抄録

After an upper half of dog bladder was excised and repaired with gelatin sponge sprayed with Nobecutane, blood supply and nerve regeneration during the developing process of new bladder wall were observed.
1) Blood supply to new bladder wall
The blood supply was investigated by dye injection method and microangiography. At an early period after the bladder repair, newly formed connective tissue at the bladder defect is receiving blood principally from the organs adhereing to the outer surface of the grafted portion. As adhesion becomes loose with time and muscle regeneration progresses toward the center of grafted portion, blood flow from original bladder wall increases in rate and finally normal distribution of blood vessel is established in the new bladder wall 8 months later.
2) Regeneration on nerve
The nerve regeneration was investigated with histochemical techniques. Adrenergic and cholinergic nerves adjacent to vessels are found near the cut edge of the bladder wall in early period after bladder repair. Then nerves adjacent to vessels extend to the central part of the new bladder wall with growth of blood vessels from cut edges of the bladder, and a little later nerves unrelated to vessels also extend with progression of muscle regeneration from the cut edges. Finally, adrenergic and cholinergic nerves are distributed in the new bladder wall as about equally as normal bladder wall, but ganglion cells are never seen in the new bladder wall.