IMMUNOLOGIC ALTERATIONS IN BLADDER TUMORS I
HUMORAL IMMUNITY, ESPECIALLY IMMUNOGLOBULIN
1978 Volume 69 Issue 2 Pages 188-196
Details
1978 Volume 69 Issue 2 Pages 188-196
The immunoglobulin-levels (IgG, IgA and IgM) of 50 bladder tumors, 50 follow up cases of bladder tumor, 20 patients with urogenital malignant tumor outside the bladder (other malignant disease group), 8 benign urogenital diseases (hospital control group) and 10 normal volunteers were measured with the technique of single radial immunodiffusion on Hyland immuno-plate. Bladder tumors were divided into two groups: low grade low stage group (LG group) and high grade high stage group (HG group) by Broders' and Jewett's classification.
1) Only IgM level of bladder tumors (both LG and HG groups), malignant tumor group and hospital control group is higher than normal group, but IgG and IgA levels are within normal limits. IgM level of LG group is significanly lower than that of malignant tumor group and HG group by student's p-test.
2) There exists a definite correlation between tumor grade and IgM-level, namely high IgM level has high malignancy, but there were no relationship between tumor stage and immunoglobulin-level.
3) Comparison of immunoglobulin-level of recurrent bladder tumor group and recurrent free group was also performed, only IgM-level of recurrent group was relatively higher than that of recurrent free groups, but this was not significant by p-test.
4) Clinical usefulness of immunoglobulin-level could not be firmly proved, though it furnished us a basis for a supplementaly judgement of tumor grade.
