METHOD FOR CLINICAL EVALUATION OF ANTIMICROBIAL AGENTS ON URINARY TRACT INFECTIONS
I. Criteria for Simple Urinary Tract Infections
1979 Volume 70 Issue 3 Pages 317-326
Details
1979 Volume 70 Issue 3 Pages 317-326
A method for clinical evaluation of antimicrobial agents on simple urinary tract infections was reported.
The outlines were summarized as follows,
1) Acute simple cystitis of the female aged from 16 to 59 years old was adopted as an object to keep the condition constant.
2) Pain on urination, pyuria over 10 cells/hpf and bacteriuria over 104CFU/ml were considerd to be necessary for the diagnosis.
3) Clinical efficacy of the drug was estimated after 3 days' treatment.
4) Overall clinical efficacy was evaluated based on the response of symptom, pyuria and bacteriuria.
5) Overall clinical efficacy was classified into 3 degrees; excellent, good and poor (or failed).
However, it was not agreeable to compare the rate of “excellent” between drugs, because the back ground characters of patients such as degree of pyuria before treatment or age sometimes affect the rate.
