CORRELATION BETWEEN DRUG SENSITIVITY AND CLINICAL EFFECT IN URINARY TRACT INFECTIONS

Abstract

Correlation between the disc sensitivity and the clinical effect were investigated in 205 cases with acute simple cystitis and also in 283 cases with chronic complicated urinary tract infection (UTI).
The results were summarized as follows.
1. Significant correlation between the disc sensitivity and the bacteriological response were observed in cases with acute simple cystitis treated with 1g or 0.5g of ampicillin, but the correlation in cases treated with 2g of ampicillin was not significant.
2. Dose response in acute simple cystitis was significant only in cases with resistant strains, which were judged by the negativity of the disc sensitivity test.
3. Significant correlation between the disc sensitivity and the bacteriological response was also observed in cases with chronic complicated UTI treated with ampicillin or carindacillin, but correlation in cases treated with gentamicin was not significant.
4. In comparison with acute simple cystitis and chronic complicated UTI, both treated with 2g of ampicillin, bacteriological eradication rate was higher in acute cases than chronic cases both in the sensitive and resistant group. But the difference of eradication rate between acute and chronic cases was more obvious in the resistant group.
5. It was considered sufficient to divide the sensitivity of causative organisms into two groups, “sensitive” which was judged (+++)-(+), and “resistant” which was judged (-) by the disc sensitivity test.
6. From these results, the disc sensitivity test was considered useful in predicting the clinical efficacy of chemotherapy of UTI.