1979 Volume 70 Issue 3 Pages 337-341
Prepubertal hypospadias (n=15, age 2-3/4-5-5/6) were investigated for male gonadal functions, which consisted of bone age, length of phallus, type of hypospadia, plasma LH on LH-RH (100μg, i. v.) and plasma testosterone on HCG (fourth day after 10000 I. U., i. m.).
Bone ages were retarded in five cases and the phallus was smaller than normal Japanese boys in fourteen cases. Plasma LH was low (1-5 mIU/ml) and responses on LH-RH were meaningful in nine cases as normal prepubertal boys. Plasma testosterone was low (0.2-0.8ng/ml) and responses on HCG were meaningful in twelve cases as normal prepubertal boys.
Responses on both LH-RH and HCG were meaningful in nine cases and poor in three cases, therefore the former were presumed to have normal pituitary-gonadal axis and the later to be hypogonadism. Bone age, length of phallus and type of hypospadia were not correlated with the results of LH-RH and HCG tests in our series.
