1979 Volume 70 Issue 4 Pages 403-409
The levels of EM and ABPC-MCIPC in the prostatic tissue and the prostatic fluid of the dog were determined.
1. EM: The maximum concentration in the prostatic tissue after single oral dose of EM 50mg/kg was 2.20μg/g and prostatic tissue/serum ratio was 1.49. The maximum level of EM in the prostatic fluid was 8.95μg/ml and prostatic fluid/serum ratio was 4.40.
2. ABPC-MCIPC: The concentrations in the prostatic tissue and the prostatic fluid after single oral dose of ABPC 25mg/kg and MCIPC 25mg/kg was scarcely detectable.
The concentrations of SMX-TMP in the seminal plasma of normal adult and in the adenoma tissue of patients with prostatic hyperplasia were determined.
1. SMX: The maximum concentration of SMX in the prostatic tissue after single oral dose of SMX 800mg and TMP 160mg was 20.6μg/g and prostatic tissue/serum ratio was 0.366. The maximum level in the seminal plasma was 6.5μg/ml and semen/serum ratio was 0.151.
2. TMP: The maximum concentration of TMP in the prostatic tissue was 6.89μg/g and prostatic tissue/serum ratio was 3.82. The maximum level of TMP in seminal plasma was 5.75μg/ml and semen/serum ratio was 2.90.
