PLATELET-LIKE BODIES AND 5-HYDROXYTRYPTAMINE IN URINE
I. Their Relationship to Renal Functions
1980 Volume 71 Issue 3 Pages 232-238
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1980 Volume 71 Issue 3 Pages 232-238
We have already reported that platelets and/or cell elements originating from platelets are always involved in urine of normal and sick persons. (The small bodies were termed “platelet-like bodies in urine”-U-PLB). Transmission electron micrographs of the small bodies fixed with glutaraldehyde and osmium often showed the dense body which is considered as the storage organelle of 5-hydroxytryptamine (5-HT).
There is not an article on the separate determination of 5-HT in the urinary sediment and supernatant, nor an article on the relation between 5-HT in urine and blood and the renal function.
In 32 cases having various renal functions (Ccr; 68.8±31.7, range; 126.9-11.2ml/min) the endogeneous creatinine clearance test (Ccr) for 24 hours was done and the values of 5-HT in daily urine and blood were assessed.
The average values of 5-HT in the urinary sediment and the supernatant were 57.88μg/dl and 33.35μg/dl respectively and in 23 cases out of 30 cases (77%) the former was higher than the latter. These examinations of 5-HT suggested that platelet-like body is present in urine.
The average values of 5-HT in the whole blood and the platelet rich plasma (PRP) were 11.71μg/dl and 23.94μg/dl respectively and were lower than those in the urinary supernatant. The values of Ccr were significantly related to the values of 5-HT in the urinary supernatant and the daily excretion values of 5-HT in urine, and the values of 5-HT in the whole blood were significantly related to the values of C5-HT. In 4 cases out of 32 cases (12.5%) the values of 5-HT in the whole blood were higher than those in the urinary supernatant, and all of them were suffering from chronic glomerulonephritis. Therefore, we should give carefull consideration of the renal function to the investigation of 5-HT in urine. The values of urinary 5-HIAA were significantly related to the urine volumes, but those were not related to the values of 5-HT in urine and in blood and the renal functions.
