1980 Volume 71 Issue 6 Pages 607-613
The pre-transplant serum samples from 38 living related renal transplant recipients were screened for cytotoxic antibodies against a panel of B and T lymphocyte at 4°C and 37°C. The cytotoxicity positive sera were classified into three patterns: the T warm pattern which reacts with greater than 15% of T lymphocyte panel at 37°C; the B warm pattern which reacts with greater than 15% B lymphocyte panel and reacts less than 15% of T lymphocyte panel at 4°C and 37°C; and the B cold pattern which reacts with greater than 15% of B lymphocyte at 4°C and does not react under other conditions. According to the serum patterns, the patients were divided to four groups: T warm group, B warm group, B cold group and No antibodies group. The B cold group with history of blood transfusion had a higher graft survival rate than other groups. The B cold group without history of blood transfusion and B warm group did not have good graft survivals. The B cold cytotoxins as a product of blood transfusion seems to have an enhancing effects on living related kidney allografts.
