STUDIES OF URODYNAMICS

VIII. Clinical and Experimental Studies of Effects of Prostaglandin E₂ and Prostaglandin F_2α on Lower Urinary Tract

Abstract

Clinical and experimental studies were made on the effect of prostaglandin F_2α (PGF_2α) and prostaglandin E₂ (PGE₂) on the lower urinary tract. PGF_2α and PGE₂ were administered intravenously to female mongrel dogs under general anesthesia using α-chloralose. Both prostaglandins caused slight elevation of bladder pressure and reduction of urethral pressure. In cases of women who had lower motor neuron lesion, oral administration of 16-(3-trifluoromethylphenoxy)-ω-tetranor-trans-Δ²-PGF_2α methyl ester caused elevation of tonus limb on cystometrogram and had no effect on urethral pressure profile and uroflowmetry.