URINARY ACIDIFICATION IN UNILATERAL OBSTRUCTIVE UROPATHY

Studies on Urinary Acidification III

Abstract

In unilateral hydronephrosis, GFR and urinary concentration ability are significantly decreased in hydronephrotic kidney than normal kidney. To investigate the degree of defect of urinary acidifying function in hydronephrotic kidney of unilateral hydronephrosis, urinary weak acids are examined by urinary titration curve analysis after the load of oral ammonium chloride.
The results are as follows:
1) The urinary TA, NH₄⁺, and net H⁺ were significantly decreased in hydronephrotic kidney compared to normal kidney in acid load test.
2) However, comparing the acid excretion per nephron which was obtained from the value of the acid excretion divided by GFR, no significant difference was observed between the hydronephrotic kidney and normal kidney. But in severe hydronephrosis such as those of grade D and E, the acid excretion per nephron was decreased than others.
3) In normal kidney, urinary acid excretion was much increased in compensation.