1983 Volume 74 Issue 5 Pages 765-769
A clinical study was performed on 50 patients who received kidney allografts from living related donors since Sept., 1973, through July, 1980, at Shakai Hoken Chukyo Hospital. The analysis was done in two separated groups. The group I (G-I) includes 20 transplants performed from Sept., 1973, through Dec., 1975, and group II (G-II) includes 30 transplants performed from Jan., 1976 throuth July, 1980. The reason why materials were devided into two groups was that a new postoperative regimen has been accepted since Jan., 1976. The essence of new postoperative regimen was low dose immunosuppressive therapy after transplantation.
The results were as follows.
1) Patient survival in G-II showed considerable improvement over that of G-I. One year survival rate was 70% in G-I, 97% in G-II and 3 year survival rate was 55% in G-I, 92% in G-II.
2) Comparison of the graft survival curves in G-I and G-II shows no considerable difference. One year survival of allografts were 65% in G-I, 70% in G-II and 3 year survival of allografts were 45%in G-I, 62% in G-II.
3) The deaths caused by infectious disease accounted for only 2 cases in G-II, compared with 5 cases in G-I.
4) Major infectious complications were occurred 41 times in 14 cases in G-I, and 15 times in 11 cases in G-II within 3 months after kidney transplantation.
