1985 Volume 76 Issue 2 Pages 204-210
A clinical analysis was made on 11 patients with disseminated intravascular coagulation (DIC) in urological malignancies in the last 5 years.
The average age of the patients was 65.6 years. Prostatic cancer and bladder cancer were found frequently as their primary lesions. The average duration of the disease was 213.6 days and metastases were found in all the cases at the onset of DIC.
Regarding treatments for respective primary lesions at the onset of DIC, 3 cases were treated only symptomatically, and the remaining 8 were given anti-tumor agent, radiotherapy, hormonal therapy, interferon, immunotherapy and hyperthermia.
The average duration from the time of onset of primary lesions to onset of DIC was 35.7 months, and that from the time of onset of DIC to the death was 71.6 days. These findings were compatible with characteristic pictures in chronic DIC. Curative treatments for DIC were performed only in 4 cases.
The incidence of abnormal levels of platelet count, FDP and fibrinogen were similar to that of other DICs. Prothrombin time and thrombin time, however, were lower than in other DICs. Autopsy showed fibrin thrombi in 5 of 8 cases.
The present study suggest that in order to prevent the development of DIC in urological malignancies, primary lesions must be treated in early stages and that good prognosis of DIC might be obtained if the treatments of DIC were started in early stages to cope rapidly with changes of DIC conditions.
