SENSITIVITY TESTS OF ANTI-CANCER DURGS WITH HUMAN TUMOR STEM CELL ASSAY
2. The Results of Renal Cell Carcinoma and Urothelial Carcinoma
1985 Volume 76 Issue 5 Pages 645-648
Details
1985 Volume 76 Issue 5 Pages 645-648
The chemosensitivity testing with a stem cell assay for renal cell cancer and urothelial cancer (renal pelvic cancer and bladder cancer) were examined.
Colony formation in soft agar dish were observed in 29 of 40 (72.5%) tumors of renal cell cancer patients and in 9 of 12 (75%) tumors of urothelial cancer patients. Plating efficiencies of them were 0.02 to 0.5% and 0.02 to 0.2%, respectively.
In vitro sensitivity to a few anti-cancer drugs was observed in only a few cases with renal cell cancer.
Whereas sensitivity was obtained in more than half urothelial cancer patients to several anti-cancer drugs, i. e., vinblastine, cis-platinum, adriamycin and aclacinomycin. These results seem to be consistent with the clinical situation of chemotherapy for these two urogenital malignancies.
