1985 Volume 76 Issue 5 Pages 649-657
The clinical result was studied in 33 living and 27 cadaveric renal transplantations performed at our department during the period from November, 1979 to May, 1984.
In living transplantation, the one year survival rates of the patients and the grafts were 89.7% and 79.9%, respectively. The one year graft survival rate of early 9 cases (LD 1-9) receiving steroides and azathioprine as the immunosuppressants was 55.6%. On the other hand, it has improved to 95.2% in the recent cases (LD 10-33) after the immunosuppressive method was switched to the main combination of preoperative lymphapheresis, steroids and mizoribine (Bredinin).
In 27 cadaveric transplantations, of which 13 were performed with kidneys imported from the United States (U. S. kidneys) and 14 with domestic kidneys obtained from Shizuoka-ken (domestic kidneys), the one year survival rates of the patients and the grafts were 72.0% and 53.7%, respectively. When the graft survivals of the U. S. and domestic kidneys were compared, that of the domestic kidneys showed a better result -75.0% in contrast to 39.8% of the U. S. kidneys. From these results, public recognization of the necessity of harvesting domestic kidneys should be urged throughout Japan.
Serious complications, mainly interstitial pneumonia, were mostly observed during the ATN period after cadaveric transplantation.
Obtaining kidneys immediately after the death and finding out the proper immunosuppressive method during the ATN period might be stressed to avoid fatal complications.
