1985 Volume 76 Issue 6 Pages 843-849
Previous study has shown that high-Ca diet develops severe renal tubular calcium oxalate deposition in rats on a hyperoxaluric protocol of ethylene glycol administration. The present study was conducted to investigate the preventive effects of phytin (extracted from rice-bran) and sodium citrate on intratubular calcium oxalate. These objectives were estimated using a histological grading (Grade 0-Grade 3) and calcium contents of whole renal tissue.
When rats fed by high-Ca diet were supplemented with phytin (3g/100g diet), a partial but significant protection aginst calcium oxalate deposition was achieved histologically and biochemistrically. It appeared that the hypocalciuric action of phytin was attributed to the inhibition of crystal formation.
Investigations of the effect of citrate on calcium oxalate crystal in rats were carried out continuous by administration of sodium citrate (0.5%-2.5%), giving drinking water ad libitum. There were significant inhibitions of renal deposition of calcium oxalate by addition of citrate, even at the lowest concentration (0.5%). The effectiveness of the protection of calcium oxalate crystal was ocrrelated directly with the level of citrate concentration.
