1987 Volume 78 Issue 11 Pages 2004-2010
Histological mapping of the bladder was performed in 42 surgical total cystectomy specimens. Removed bladders were opened by an anterior incision accordsng to the general rule for clinical and pathological studies on bladder cancer of Japanese Urological Association. Fixed tissue was cut into 5×20mm sized blocks. The areas of blocks including the tumor tissue and comprising histologicallly identified cancer cells were measured.
There were no significant differences among groups pT1, 2, 3 and 4 in clinical tumor areas. In pT2, 3 and 4 groups the areas of blocks comprising cancer cells histologically were greater than that of the clinical tumor. Every specimen showed diffuse epithelial abnormalities such as proliferative cystitis, squamous cell metaplasia and other degenerative changes. The blocks had evidence of these changes were occupied to equal or surpass the blooks comprising the cancer cells. These areas in groups pT3 and 4 were significant greater than that of pT1 and 2. The tumor invaded progressively to the deep muscle layer of bladder had marked tendency to spread diffusely.
