Abstract
Primary transitional cell carcinoma of the prostate and the prostatic involvement by the transitional cell carcinoma of the urinary bladder are sometimes difficult to differentiate even in terms of histology. Moreover, the prostatic involvement by transitional cell carcinoma of the urinary bladder is more frequently observed than the primary transitional cell carcinoma of the prostate. Therefore, in this report, the characteristics of the prostatic involvement by transitional cell carcinoma of the urinary bladder was examined in 173 cystoprostatectomized specimens for bladder cancer.
The prostatic specimens were examined by step sectioning and were divided into “no malignancy” group and “prostatic involvement” group.
Significant clinical and pathological findings in the “prostatic involvement” group were; (1) dysuria was more frequently observed, (2) invasive carcinoma was more prominent, (3) urethral recurrence was more frequently seen. The above findings were also coincident with the charactristics of the primary transitional cell carcinoma of the prostate. From the case reports in the first report and their comparison with adenocarcinoma of the prostate, and transitional cell carcinoma of the urinary bladder, the origin and development of transitional cell carcinoma of the prostate, and the relationship with transitional cell carcinoma in the urinary bladder as well as multiple urothelial carcinoma in the urinary tract were discussed from the anatomic, embryonic and carcinogenic standpoint. From the practical, therapeutic view point, we admit the concept of primary transitional cell carcinoma of the prostate, but at the same time we must also think about the possibility that the case is a special type of transitional cell carcinoma in the urinary bladder or prostatic involvement by multiple urinary tract cancer. The most suitable treatment appears to be cystoprostatectomy with or without urethrectomy and pelvic lymph nodes dissection. When one-stage urethrectomy is not performed, it is mandatory to periodically check the possibility of reccurence in the urethra in these cases.
