AN EXPERIMENT TO ESTIMATE CREATININE CLEARANCE OF CHRONIC UNILATERAL AND COMPLETELY OBSTRUCTED KIDNEY
1988 Volume 79 Issue 6 Pages 1019-1024
Details
1988 Volume 79 Issue 6 Pages 1019-1024
The following experiment was performed to estimate the kinetics of renal pelvic creatinine in chronic unilateral and completely obstructed kidney and values of creatinine clearance.
Hydronephrosis was prepared in 20 mongrel dogs up to 5-40 days in a period during when a unilateral ureter was obstructed by complete ligature and the renal pelvic urine was replaced with physiological saline to measure the change in renal pelvic creatinine with time. Further, creatinine clearance was estimated from renal pelvic capacity and serum creatinine concentration.
Creatinine was excreted into the renal pelvis even in the completely obstructed kidney.
Values of creatinine clearance were 0.36±0.09, 0.19±0.08, 0.09±0.05 and 0.09±0.05 and 0.09±0.05ml/min/10kg body weight (mean S. D., n=5) in 5, 10, 20 and 40 days, respectively, during the period of obstruction.
The amount of hydronephrotic creatinine in 40 days during the period of obstruction was less than the estimated creatinine amount, suggesting that the creatinine once excreted was obsorbed again in the chronic completely obstructed kidney.
This experimental method was considered adequate for estimating the renal function in chronic complete obstruction of the ureter.
